Cutting down unneeded antibiotics for HIV patients in Mozambique

De-implementation strategy to reduce unnecessary antibiotic prescriptions for ambulatory HIV-infected patients with upper respiratory tract infections in Mozambique: a study protocol of a cluster randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN88272350

Enrollment

422

Registered

2024-05-16

Start date

2024-06-01

Completion date

Unknown

Last updated

2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

De-implementation of antibiotic use among ambulatory HIV-infected adults with upper respiratory tract infection Infections and Infestations

Interventions

A multicenter two-arm cluster randomized controlled implementation science trial will be undertaken employing a mixed-methods approach. This study will be guided by two conceptual frameworks, the Dyna

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Adult HIV-infected patients with URTI symptoms 2. Frontline healthcare workers in selected primary healthcare clinics providing HIV care and treatment services

Exclusion criteria

Exclusion criteria: 1. Adult HIV-infected patients without URTI symptoms 2. Fever =39ºC 3. Severe mental illness 4. Advanced HIV status

Design outcomes

Primary

Measure	Time frame
Appropriate non-prescription of antibiotics for upper respiratory tract infection measured using study data collected on a registration form on the day of a medical visit and 5 or 10 days after the initial visit if not recovered	—

Secondary

Measure	Time frame
1. The proportion of clinicians who adopted the de-implementation strategy measured using study data collected on the registration form on the day of a medical visit and 5 or 10 days after the initial visit if not recovered 2. Clinician satisfaction with the use of the clinical decision support algorithm measured using an in-depth interview record and a 5-point Likert scale at 6 months of the intervention period (the end of the intervention phase) 3. Fidelity to the de-implementation strategy measured using study data collected on the registration form at the end of the intervention phase 4. Feasibility of use of the clinical decision support algorithm measured using study data collected on the registration form and in-depth interview records at the end of the intervention phase	—

Measure

Time frame

1. The proportion of clinicians who adopted the de-implementation strategy measured using study data collected on the registration form on the day of a medical visit and 5 or 10 days after the initial visit if not recovered 2. Clinician satisfaction with the use of the clinical decision support algorithm measured using an in-depth interview record and a 5-point Likert scale at 6 months of the intervention period (the end of the intervention phase) 3. Fidelity to the de-implementation strategy measured using study data collected on the registration form at the end of the intervention phase 4. Feasibility of use of the clinical decision support algorithm measured using study data collected on the registration form and in-depth interview records at the end of the intervention phase

—

Countries

Mozambique

Contacts

Public ContactCandido Faiela

candido.faiela@gmail.com+258 847145631

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 11, 2026