Early asymptomatic coronary artery disease in diabetic patients Circulatory System Coronary artery disease
Conditions
Interventions
A randomized prospective study of medical therapy versus invasive evaluation of CAD and subsequent revascularization
Sponsors
University Hospital Basel - Department of Cardiology (Switzerland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with diabetes type 2, asymptomatic with respect to angina, no prior coronary artery disease; high risk profile for coronary artery disease (pathologic electrocardiogram [ECG], peripheral vascular disease, microalbuminuria, cardiac autonomic neuropathy, retinopathy, or more than one addititional risk factor for CAD).
Exclusion criteria
Exclusion criteria: Concomitant disease with prognosis less than 3 years survival. Older than 75 years. End stage renal disease or dialysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac death, myocardial infarction, onset of angina, or hospitalization (for acute coronary syndrom or symptomatic need for revascularization). Myocardial perfusion changes over time: Evolution of ischemic burden and overall abnormality. | — |
Secondary
| Measure | Time frame |
|---|---|
| Angina class, quality of life, impact of medical therapy. Myocardial perfusion single photon emission computed tomography (SPECT) variables. Left ventricular ejection fraction, volumes. | — |
Countries
Switzerland
Outcome results
None listed