Anaemia Haematological Disorders Other anaemias
Conditions
Interventions
Randomised controlled trial:
1. Group O will receive a 6 week course of oral iron therapy
2. Group I will receive a 200 mg intravenous dose of iron sucrose
3. Group E will receive a 200 mg dose of iro
Sponsors
Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 45 patients in 3 groups. 1. Pre-operative inclusion criteria: 1.1. All patients who are due to undergo major gynae-oncological surgery 1.2. Aged greater than 18 years 2. Post-operative inclusion criteria: 2.1. Iron deficiency type anaemia due to peri-operative blood loss 2.2. Haemoglobin (Hb) less than 10 g/dl on day 1 following surgery
Exclusion criteria
Exclusion criteria: 1. Pre-operative exclusion criteriaL 1.1. Patients requiring peri-operative therapeutic anti-coagulant therapy 1.2. Pre-operative anaemia 1.3. Liver disease 1.4. Chronic renal failure 1.5. Uncontrolled hypertension 1.6. Ischaemic heart disease requiring a transfusion threshold above 7 g/dl 1.7. History of anaphylaxis to oral iron sulphate, iron sucrose or epoietin alpha 2. Post-operative exclusion criteria: 2.1. Severe anaemia requiring transfusion of red cells: Day 1 [Hb] less than 7 2.2. Massive blood transfusion associated with disseminated intravascular coagulation (DIC) 2.3. Continuing requirement for blood product administration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in haemoglobin levels from day 1 to day 21 2. Change in ferritin concentration 3. Change in transferritin 4. Quality of life scores 5. Post-operative blood transfusion 6. Length of stay | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed