Lactobacillus rhamnosus GG (ATCC 53103) in the treatment of infantile colic

Assay of IL6 and TNF alfa in infantile colic treated with Lactobacillus GG

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN87937882

Enrollment

Registered

2021-09-09

Start date

2021-07-23

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infantile colic Signs and Symptoms Colic, infantile

Interventions

At enrollment, each infant underwent a medical examination by a pediatrician, and parents completed a questionnaire to obtain data concerning the type of delivery, birth weight, and gestational age. T

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Infants aged between 2 and 10 weeks 2. Gestational age between 37 and 40 weeks 3. Birth weight between 2700 and 4200 g 4. Exclusively breastfed

Exclusion criteria

Exclusion criteria: 1. Clinical evidence of chronic illness or gastrointestinal disorders 2. Received antibiotics or probiotics in the week preceding recruitment

Design outcomes

Primary

Measure	Time frame
Crying time per day measured by parents using a structured diary for the 28 days of the study period	—

Secondary

Measure	Time frame
Interleukin 6 and tumor necrosis factor alfa evaluated with real-time PCR at day 0 and day 28	—

Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026