Infants fully formula feeding after birth Infections and Infestations Infants fully formula feeding after birth
Conditions
Interventions
Eligible infants were randomly assigned to one of the two intervention groups. Infants in the intervention group (IG) were given a commercially available bovine colostrum (BC) sachet (Hainan Govking H
Sponsors
Chengdu Women's and Children's Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Apparent good health without common obstetric risk factors 2. Full term with 37-42 weeks’ gestation at birth with birth weight of more than 2500 g 3. Previously fully formula feeding after birth to 6-9 months at recruitment 4. Parent or guardian approval for participating in all aspects of the study 5. Parent or guardian agreement to avoid additional BC and probiotic products during the investigation
Exclusion criteria
Exclusion criteria: 1. History of severe, persistent, or chronic diarrhea 2. Severe malnutrition 3. Serious infections requiring hospitalization in the month prior 4. Serious chronic illness 5. Personal or family history of allergy to cow’s milk or intact infant formula 6. Eczema 7. Allergic rhinitis 8. Asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following are assessed using patient interviews throughout the 3 month intervention period: 1. Morbidity of diarrhea 2. Respiratory tract infections | — |
Secondary
| Measure | Time frame |
|---|---|
| The following are assessed at the baseline and after 3 months: 1. Duration of respiratory-related illnesses, assessed using patient interviews 2. Duration of diarrhea-related illnesses, assessed using patient interviews 3. Growth levels of infants, assessed by measuring their weight, length and head circumference 4. Family functional scores assessed using PedsQL™ 2.0 Family Impact Module 5. Levels of the following, assessed using ELISA of fecal samples: 5.1. IgA 5.2. Calprotectin 5.3. Total fatty acid | — |
Countries
China
Outcome results
None listed