Surgical extraction of impacted mandibular third molars Oral Health
Conditions
Interventions
I Group: I Group – 30 patients received one dose of local anesthetic solutions: 4 ml of local anesthetic 0.5% ropivacaine chloride (ROPIvacaine 5 mg/mL, B|Braun Melsungen AG, 34209 Melsungen, Germany)
III Group – 30 patients received one dose of local anesthetic solutions: 5 mL of local anesthetic 0.5% bupivacaine (Marcaine®, 0.5% Astra Zeneca, Sodertalje, Sweden)
Sterile disposable plastic syringes of 5 mL capacity were used in all groups as containers for the local anesthetics, with the expiration dates checked beforehand. A sterile 21 G × 1½” (0.8 × 40 mm) n
Sponsors
University of Niš
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for surgical extraction of impacted mandibular third molar for the first time 2. Diagnosed as horizontal impaction according to Winter’s classification 3. Patients classified as American Society of Anesthesiologists (ASA) physical status I (ASA I) 4. Absence of pain, swelling or trismus during the 2 weeks prior to surgery 5. Absence of systemic infection or pericoronitis 6. No known allergies to local anesthetics, analgesics, or dexamethasone 7. No antibiotic therapy within 14 days prior to the surgical removal of the impacted mandibular third molar teeth
Exclusion criteria
Exclusion criteria: 1. Patients classified as ASA II–VI according to the American Society of Anesthesiologists classification 2. Patients with systemic diseases 3. Individuals who had experienced major stressful life events within the previous 6 months (e.g., death of a close family member, divorce, or job loss) 4. Patients engaged in high-stress occupations and shift work 5. Smokers 6. Patients who had used or were currently using psychoactive medications, sedatives, anxiolytics or antidepressants 7. Pregnant or breastfeeding women 8. Women using oral contraceptive pills
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative salivary cortisol levels measured using enzyme-linked immunosorbent assay (ELISA) at baseline on the day of the surgery, 15 min before anesthesia (08:00–09:00 am), 15 minutes after surgery and postoperative day 1 (08:00–09:00 am) | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative anxiety measured using the Revised Norman Corah Dental Anxiety Scale at baseline (on the day of the surgery, 30 min preoperatively);Duration of conduction anesthesia, defined as the time from onset of lower lip numbness to full measured using data collected from study records at one time point;Duration of postoperative analgesia, defined as the time from the end of surgery to first pain requiring analgesic intake measured using data collected from study records at one time point;Postoperative analgesic consumption, defined as the total number of ibuprofen doses taken within 24 hours post-surgery measured using data collected from study records at one time point | — |
Countries
Serbia
Contacts
Public ContactMiloš Kostic
Outcome results
None listed