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Rehabilitation of Patients with Rheumatoid Arthritis (RA): Changes in Muscle, Functional and Biochemical Parameters

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN87704142
Enrollment
133
Registered
2004-01-23
Start date
1996-04-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthritis (rheumatoid) Musculoskeletal Diseases Other rheumatoid arthritis

Interventions

The intervention consisted of 10 exercise sessions (twice a week for 5 weeks) at a hospital out-patient department. Exercises were tailored to address each individual patient's disabilities.

Sponsors

Record Provided by the NHS R&D 'Time-Limited' National Programme Register - Department of Health (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with knee and elbow rheumatoid arthritis. 1. Knee study: 133 participants were recruited to the cross-sectional study, 108 RA patients and 25 healthy participants. 93 patients were recruited to the rehabilitation trial. 2. Elbow study: 21 participants were recruited to the cross-sectional study, 12 patients with RA and 9 healthy participants. These 12 patients participated in the rehabilitation study.

Exclusion criteria

Exclusion criteria: Does not match inclusion criteria

Design outcomes

Primary

MeasureTime frame
1. Knee Study: Isometric quadriceps strength 2. Elbow Study: Elbow flexor strength

Secondary

MeasureTime frame
1. Knee Study: 1.1. Voluntary quadriceps activation 1.2. Knee joint position sense 1.3. 4 common activities of daily living 1.4. Health Assessment Questionnaire (HAQ) 1.5. Disease Repercussion Profile 1.6. Clinical measures if disease activity in RA 1.7. Serum concentrations of IL-1, IL-6, TNF-alpha 2. Elbow Study: 2.1. Voluntary flexor activation 2.2. Elbow joint position sense 2.3. HAQ 2.4. Arthritis Impact Measurement Scale-2 2.5. Clinical measures of disease activity

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026