Vasovagal syncope Circulatory System
Conditions
Interventions
Participants will be randomised in a simple fashion to either sodium chloride supplementation (SALT) or salt and glycerol (SALT+) for 1 week.
Sponsors
Ministry of Defence
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy with no active medical treatment or taking regular medications or supplements (excluding contraceptives) 2. Aged 18-55 years Participants who entered into the RCT aspect of the study: 3. Prior orthostatic mediated syncope or prior non-orthostatic mediated reflex syncope
Exclusion criteria
Exclusion criteria: 1. Individuals who are competing in competitive sports, for which glycerol supplementation is forbidden by WADA, will be excluded. 2. Volunteers taking ergogenic supplements within in the last month will be excluded. 3. Any participant with ongoing medical condition(s) which could be worsen with expansion of plasma volume will be excluded including those whom identify as having cardiovascular or neurological disease. 4. Participants taking prescription medications which could interfere with testing will be excluded 5. Participants who are pregnant or whom believe they may be pregnant, will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to presyncope as measured for head-up tilt with lower body negative pressure pre and post intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| A difference in cardiovascular variables during head up tilt with lower body negative pressure pre and post intervention | — |
Countries
England, United Kingdom
Outcome results
None listed