Management of unexplained infertility

Cervical mucus removal prior to intrauterine insemination: can it improve pregnancy rates in women with unexplained infertility?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN87670645

Enrollment

714

Registered

2014-10-27

Start date

2014-10-29

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical mucus removal Pregnancy and Childbirth

Interventions

Patients will be randomized into two groups: Group A: cervical mucus removal group Group B: non-cervical mucus removal group, where only the external cervical os will be cleaned

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Women aged 35 years or less 2. Body mass index (BMI) 30 kg/m2 or less 3. Diagnosis of unexplained infertility. The diagnosis of unexplained infertility was made according to the following points: normal semen analysis based on World Health Organization criteria (11), a preliminary transvaginal scan (TVS) on Day 2 of the cycle is normal with no detected ovarian pathology, normal (10 mg/dL, normal uterine cavity on hysterosalpingography or hysteroscopy, and patent tubes of normal appearance on hysterosalpingography and/or laparoscopy.

Exclusion criteria

Exclusion criteria: 1. Women aged over 35 2. Hypogonadotrophic hypogonadism 3. Diminished ovarian reserve (basal FSH level >10 IU/ ml) 4. Presence of resistant ovarian cyst (>20 mm for >1 month)

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate (defined as ultrasound evidence of pregnancy or products of conception identified by histopathological examination) per patient at 2 weeks following IUI	—

Countries

Egypt, Saudi Arabia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026