Prevention of elevated cholesterol by lowering circulating PCSK9 in metabolically healthy people with obesity Nutritional, Metabolic, Endocrine
Conditions
Interventions
Volunteers willing to participate and practice intermittent fasting for 4 consecutive weeks from dawn to sunset are recruited. Body weight, height, and body measurements, blood samples and food intake
Sponsors
University of Sharjah
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Metabolically healthy male or female adult subject (>18 years) 2. Overweight/obesity (body mass index (BMI) >25 kg/m²) 3. Willing to fast for consecutive four weeks from dawn to sunset, and willing to participate and sign the informed consent
Exclusion criteria
Exclusion criteria: 1. History of metabolic syndrome, diabetes, or cardiovascular disease 2. Taking regular medications or supplements 3. Following a weight-reducing diet 4. History of bariatric surgery within the last 6-9 months before commencing intermittent fasting 5. Pregnant or peri-menopausal woman
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood PCSK9 levels measured using enzyme-linked immunosorbent assay (ELISA) at baseline (pre-fasting) and after 4-week consecutive dawn to sunset intermittent fasting | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured using Analyzer machine at baseline, and after 4 weeks intermittent fasting: 1. Body weight (kg), BMI, fat mass, fat-free mass, and visceral fat surface area 2. Total cholesterol, triglycerides, HDL, LDL, fasting blood glucose | — |
Countries
United Arab Emirates
Outcome results
None listed