Using point-of-care lung ultrasound to explore how TB severity affects people’s socio-economic status

Point-Of-Care Ultrasound for Tuberculosis Formative Prospective case-control study with nested cohort in Bolivia: characterising associations between disease severity and the socioeconomic consequences of TB

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN87512724

Enrollment

300

Registered

2025-09-04

Start date

2026-03-17

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tuberculosis Infections and Infestations

Interventions

This is a 2:1 case-control study, in which adults recently diagnosed with TB attending a health care facility will be invited to participate (cases), as well as adults randomly selected from the comm

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: For participants diagnosed with TB (cases): 1. Aged =18 years old 2. Receiving or will receive treatment for pulmonary TB at the selected health centre For community controls: 1. Aged =18 years old 2. Resides in the selected community

Exclusion criteria

Exclusion criteria: For participants diagnosed with TB (cases): 1. Started treatment >2 weeks for the current TB episode 2. Refusing to provide informed consent/assent to participate in the study For community controls: 1. Received TB treatment <1 year ago 2. Refusing to provide informed consent/assent to participate in the study 3. Serious illness resulting in unstable condition or life-threatening participation in the study

Design outcomes

Primary

Measure	Time frame
Diagnostic performance of point-of-care ultrasound (POCUS) for detecting tuberculosis is measured in terms of sensitivity, specificity, positive predictive value, and negative predictive value, by comparing interpretation of ultrasound images by two independent readers to bacteriologically and/or clinically confirmed TB at baseline visit	—

Secondary

Measure	Time frame
1. Socioeconomic status measured using TB-household income at baseline 2. TB-related costs measured using a questionnaire designed for this purpose at baseline 3. Quality of life measured using the WHO BREF QOL questionnaire at baseline 4. Disease severity measured using symptom duration, body mass index, sputum mycobacterial concentration and POCUS images interpreted by two independent readers in participants with TB (cases) at baseline and 2 and 6 months	—

Measure

Time frame

1. Socioeconomic status measured using TB-household income at baseline 2. TB-related costs measured using a questionnaire designed for this purpose at baseline 3. Quality of life measured using the WHO BREF QOL questionnaire at baseline 4. Disease severity measured using symptom duration, body mass index, sputum mycobacterial concentration and POCUS images interpreted by two independent readers in participants with TB (cases) at baseline and 2 and 6 months

—

Countries

Bolivia, Peru

Contacts

Public ContactFreddy;Carlos Tinajeros;Lou

;

ftinajeros@gmail.com;carlos.a.lou.dan@gmail.com+51 (0)1 2090400;+51 (0)1 2090400

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 23, 2026