Relief of pain related to knee osteoarthritis Musculoskeletal Diseases Gonarthrosis [arthrosis of knee]
Conditions
Interventions
one dose of third-generation cephalosporin will be given for infection prophylaxis. Patients would be continuously monitored and given conscious sedation (1–2 mg IV and/or fentanyl (25–100 mcg IV)) an
Approximately 400 patients with symptomatic knee OA visit the clinic each year. A small percentage has an end-stage disease, only amenable for total knee replacement. Most of the remaining patients re
Sponsors
General University Hospital of Patras
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients of either sex will participate in the clinical trial as long as they have: 1. The NICE clinical criteria of primary knee OA for one or both knees: 1.1. Age >45 years 1.2. Activity-related joint pain 1.3. No morning joint stiffness or morning stiffness that lasts no longer than 30 minutes 2. Radiological confirmation of knee arthritis (grade =2) according to the Kellgren and Lawrence classification 3. Chronic knee pain for a minimum duration of 6 months 4. Pain intensity =4 on the (NRPS) 5. A decrease of =50% in NRPS scores with diagnostic genicular nerve block 6. The ability to communicate in Greek
Exclusion criteria
Exclusion criteria: 1. inflammatory or post-traumatic knee arthritis 2. Patients who have received CRYON or CRFA treatment in the past 3. Injection of hyaluronic acid or corticosteroid within the previous 3 months 4. Significant structural deformities affecting locomotion and knee function aside from osteoarthritis and which might cause chronic knee pain 5. Body mass index =40 kg/m² 6. Uncontrolled serious disease (cancer, diabetes, end-stage heart disease etc) 7. Unstable psychiatric illness 8. Coagulopathy or bleeding disorders 9. Active systemic or local infection 10. Disease-associated with reactions to cold, such as cryoglobulinemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain associated with knee OA measured using the Numerical Rating Pain Scale (NRPS) at 2-, 4- 12- and 24-weeks post-intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety, tolerability and the patient’s clinical outcome measured using the Knee Injury and Osteoarthritis Outcome Score (KOOS) the Oxford Knee Score (OKS) and the Patient Global Impression of Change (PGIC) 7-point scale at 12- and 24-weeks post-intervention | — |
Countries
Greece
Outcome results
None listed