Topic: Primary Care Research Network for England
Conditions
Interventions
Diet and activity modification, For 10 days, participants will be instructed to consume a glucose lowering diet. This will involve modifications to their normal diet such as replacing high GI foods wi
Sponsors
University of Bath (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male or postmenopausal* female 2. Aged between 45 to 65years 3. Waist circumference >94cm (males) or >80cm (females) 4. Weight stable for more than 3 months (no change in weight +/- 3%) Non-smoker Group 1 participants will be overweight with 'normal glucose tolerance' as defined by 2h oral glucose tolerance test (blood glucose 7.8 mmol/L but <11.1mmol/L at 2h post 75g glucose drink) *postmenopausal defined as no menstruation for at least 1 year (Witteman, Grobbee et al. 1989).; Target Gender: Male & Female; Upper Age Limit 65 years ; Lower Age Limit 45 years
Exclusion criteria
Exclusion criteria: 1. Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia 2. Taking medications that may influence lipid or carbohydrate metabolism or immune system function 3. Perform >150minutes/week moderate intensity exercise
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T cell number and activation in adipose tissue; Timepoint(s): Pre and post intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Adipose tissue cytokine secretion; Timepoint(s): Pre and post intervention 2. Adipose tissue gene expression; Timepoint(s): Pre and post intervention 3. Macrophage number and activation in adipose tissue; Timepoint(s): Pre and post intervention 4. T Lymphocyte and monocyte numbers and activation in blood; Timepoint(s): Pre and post intervention | — |
Countries
United Kingdom
Outcome results
None listed