Respiratory disease (chronic obstructive pulmonary disease) Respiratory Respiratory disease
Conditions
Interventions
1. Single leg resistance training (control):
Three supervised quadriceps resistance training sessions per week for 6 weeks.
2. Single leg neuromuscular elctrical stimulation (experimental):
Three sup
Sponsors
University Hospitals of Leicester NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of COPD 2. Forced expiratory volume in one second (FEV1) less than 50% predicted 3. FEV1/forced vital capacity (FVC) ratio less than 70% 4. Medical Research Council (MRC) dyspnoea score greater than 3 5. Clinically stable at time of recruitment (greater than 4 weeks exacerbation free) 6. Aged greater than 40 years, both sexes
Exclusion criteria
Exclusion criteria: 1. Uses long-term oral corticosteroids 2. Uses anticoagulation (e.g. warfarin) 3. Impaired clotting 4. Long-term oxygen therapy 5. Comorbid condition preventing exercise training, causing exercise limitation 6. Pulmonary rehabilitation in last 12 months 7. Condition causing intramuscular inflammation (e.g. type two diabetes [T2D], rheumatoid arthritis, inflammatory bowel disease)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle Mass: quadriceps mass change at 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Neural Adaptations to Training at 6 weeks 2. Muscle Architecture including pennation angle at 6 weeks 3. Muscle Morphology including fibre type at 6 weeks 4. Muscle hypertrophy including satellite cell activity and cross sectional area at 24 hours and 6 weeks 5. Acute local inflammation response at 24 hours and 6 weeks 6. Functional change in quadriceps strength at 6 weeks | — |
Countries
United Kingdom
Outcome results
None listed