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Intervention within the British Autism Study of Infant Siblings (iBASIS)

Intervention within the British Autism Study of Infant Siblings (iBASIS): a pilot single-blinded randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN87373263
Enrollment
50
Registered
2011-11-10
Start date
2011-05-01
Completion date
Unknown
Last updated
2017-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism Spectrum Conditions Mental and Behavioural Disorders Autism

Interventions

Two parallel groups: intervention and non-intervention. Research assessments will be made independently and blind to treatment status. The iBASIS intervention would take place in families' homes and
and the programme aims that parents will be able to do about 30 minutes of such 'practice' daily. During each session the therapist will explain clearly what the parent will be doing and parents will

Sponsors

University of Manchester (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Families live within therapist travel distance 2. Aged between 0 and 9 months at the time of referral 3. Have older sibling diagnosed with an autism spectrum disorder (ASD) 4. English spoken at home

Exclusion criteria

Exclusion criteria: 1. Child does not meet BASIS and iBASIS criteria 2. Known genetic or cognitive impairment 3. More than one infant

Design outcomes

Primary

MeasureTime frame
Autism Observation Scale for Infancy (AOSI): a validated instrument designed to measure developmental atypicality. It has shown predictive validity to later diagnosis of autism.

Secondary

MeasureTime frame
1. Coding of parent-child interaction: Global and micro measures of the parent-infant interaction coded from a free-play session. The coding aims to assess the impact of the i-BASIS intervention on parental sensitive responsiveness and dyadic mutuality. 2. Neurophyisological and brain biomarkers: The infant will complete a range of assessments including their response to social stimuli and gaze patterns 3. Qualitative analysis of parent intervention to address subjective impact of intervention

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 18, 2026