Prevention of ischemia/reperfusion injury by C1 esterase inhibitor (C1 INH): Assessment of reperfusion injury in total knee arthroplasty

Prevention of ischemia/reperfusion injury by C1 INH. Assessment of reperfusion injury in total knee arthroplasty: pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN87180032

Enrollment

Registered

2016-11-04

Start date

2017-01-01

Completion date

Unknown

Last updated

2022-01-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemia reperfusion injury after total knee arthroplasty Circulatory System Ischemia reperfusion injury after total knee arthroplasty

Interventions

Total knee arthroplasty is an elective surgical procedure that takes place when medication and/or walking support instruments can no longer relieve severe knee pain. Using a tourniquet is important to

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults aged 18-90 2. Scheduled for elective total knee arthroplasty

Exclusion criteria

Exclusion criteria: 1. Conditions which are known to influence edema formation 2. Trauma 3. Infections

Design outcomes

Primary

Measure	Time frame
Shorter tourniquet time – less expected edema of the calf muscle: Measurement of calf circumference 15 cm below knee joint before operation, immediately post OP, 4h, 24h and 48h post operative.	—

Secondary

Measure	Time frame
1. Plasma levels of CK-MM for muscle damage using an ELISA Kit 2. Plasma levels of pro-inflammatory cytokines and markers of the activation of the plasma cascade systems as well as the endothelium using different commercial available kits for each marker 3. Postoperative pain levels as assessed by postoperative use of analgesic (morphine). Assessment of the amount of morphine needed All outcomes assessed at 0, 4, 24 and 48 hours after surgery	—

Measure

Time frame

1. Plasma levels of CK-MM for muscle damage using an ELISA Kit 2. Plasma levels of pro-inflammatory cytokines and markers of the activation of the plasma cascade systems as well as the endothelium using different commercial available kits for each marker 3. Postoperative pain levels as assessed by postoperative use of analgesic (morphine). Assessment of the amount of morphine needed All outcomes assessed at 0, 4, 24 and 48 hours after surgery

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Countries

Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026