Effect of S. mansoni infection on immune responses to measles immunization

Immune Modulation and Childhood Immunization (IMoChI) Study: Immune modulation in Schistosoma mansoni infection and effects on immune responses to childhood measles immunization

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN87107592

Enrollment

275

Registered

2013-07-26

Start date

2013-02-28

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helminth infections and effects on childhood immunization Infections and Infestations

Interventions

All S. mansoni infected participants will be treated with single dose of praziquantel at the recommended dosage of 40mg per Kg body weight and children will be given measles booster immunization (in a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Children of age 3-5 years residing on the Entebbe Peninsula in Lake Victoria and adjacent islands of Wakiso district

Exclusion criteria

Exclusion criteria: 1. Children whose parents or guardian do not consent to join the study 2. Cildren who do not meet the inclusion criteria

Design outcomes

Primary

Measure	Time frame
Immune responses to Measles: Antibody responses and Cytokine responses will be measured at baseline, one week after measles booster immunization and 24 weeks after measles booster immunization.	—

Secondary

Measure	Time frame
S. mansoni infection intensity and response to praziquantel treatment will be measured at baseline and at 24 weeks after measles booster immunization.	—

Countries

Uganda

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 22, 2026