Acute ischaemic stroke and transient ischaemic attack Circulatory System
Conditions
Interventions
Baseline demographic and clinical data will be recorded by the research nurses, including variables known to be associated with outcome: age, premorbid and baseline mRS score, stroke syndrome (Oxfords
Sponsors
University of Leicester (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Acute TIA/ minor stroke (managed in an outpatient setting or with an NIHSS score <6) and stroke (managed in an inpatient setting) patients will be recruited within 24 hours of symptom onset.
Exclusion criteria
Exclusion criteria: 1. Inability to provide informed consent 2. Significant pre-stroke dependency (mRS >3) 3. Co-existing life-threatening with a life expectancy <3 months 4. Placed on an end-of-life care pathway 5. Atrial fibrillation 6. Pre-existing BB use (and need for continuation in the view of the treating clinician)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death and Dependency (Modified Rankin Score >2) at 3 months post-stroke | — |
Secondary
| Measure | Time frame |
|---|---|
| The prognostic significance of individual BPV measures from routine and enhanced casual, beat-to-beat, central, 24-hour and Home BP measurements will be assessed at the following time-points. In addition, the mRS score will be repeated and a record made of BP-lowering, statin and other treatment with vasoactive effects. 1. Short-term (72 hours) 1.1. Neurological deterioration/ improvement (NIHSS score increase/ decrease by >4 points, respectively) 2. Hospital discharge 2.1. Mortality 2.2. Recurrent TIA/stroke 2.3. Major cardiovascular events (non-fatal and fatal stroke, myocardial infarction and systemic embolism) mRS 2.4. Length of hospital stay 3. Medium-term (1 and 3 months) 3.1. Mortality 3.2. Recurrent TIA/stroke 3.3. Major cardiovascular events mRS 3.4. Cognitive dysfunction assessed using the Montreal Cognitive Assessment tool (MoCA); a brief cognitive screening tool with high sensitivity and specificity for detecting mild cognitive impairment in patients performing within the normal range of the mini-mental state examination 4. Long-term (1 year) 4.1. Mortality 4.2. Recurrent TIA/stroke 4.3. Major cardiovascular events mRS 4.4. Cognitive dysfunction assessed 4.5. Time to death/hospital re-admission | — |
Countries
United Kingdom
Outcome results
None listed