Asthma in children Respiratory Asthma
Conditions
Interventions
Low dose inhaled corticosteroids (fluticasone propionate) versus placebo
Sponsors
Wythenshawe Hospital (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Children aged 6 months to 4 years 2. Two episodes of doctor verified wheeze or one episode continuous for more than 4 weeks
Exclusion criteria
Exclusion criteria: 1. Pre-term less than 34 weeks gestation 2. Neonatal lung disease or other lung disease 3. Other chronic disease 4. Children already or previously used an inhaled corticosteroid 5. Children who cannot use the spacer device
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Occurrence of asthma at age 5 and 6 2. Lung function at age 5 3. Non-specific bronchial hyper-reactivity at age 5 4. Number of courses and total dose of add-on fluticasone propionate required | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Rescue and added asthma medication 2. Number of exacerbations 3. Safety parameters ? length/height, weight 4. Symptom scores 5. Adrenal function | — |
Countries
United Kingdom
Outcome results
None listed