Bioavailability of beetroot compounds in older adults

Bioavailability of phenolic compounds, betalain and inorganic nitrate following incremental portions of whole beetroot in older and younger adults

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN86706442

Enrollment

Registered

2017-10-24

Start date

2016-12-01

Completion date

Unknown

Last updated

2023-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age-related degenerative diseases Nutritional, Metabolic, Endocrine Age-related degenerative diseases

Interventions

Participants are randomised using a Latin-Square method. Participants are allocated in a random order to receive the four interventions. The four interventions include:

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Non-obese 2. Non-smoker 3. Males aged between 18 and 35 or 60 and 75 years 4. Free of chronic illness

Exclusion criteria

Exclusion criteria: 1. Vegetarianism 2. High blood pressure 3. Active cancer and any diagnosis of malignant cancer in the last 5 years 4. Diagnosis of chronic and acute metabolic and inflammatory conditions interfering with the study outcome 5. Medications that may have an effect on NO production 6. Hormonal therapies, statins and psychiatric drugs if dose started/changed in previous 3 months 7. Haematological disorders 8. History of repetitive gastric reflux 9. Excessive alcohol intake 10. Allergy or intolerance to the intervention food 11. Under the age of 18 12. Smoker

Design outcomes

Primary

Measure	Time frame
Differences in bioavailability of nitrate between incremental doses of beetroot and compared to a standard dose of potassium nitrate at 5 hours	—

Secondary

Measure	Time frame
1. Differences in changes in blood pressure following each dose of nitrate supplementation and compared to a standard dose of potassium nitrate at 5 hours 2. Differences in changes in endothelial function following each dose of nitrate supplementation and compared to a standard dose of potassium nitrate at 5 hours 3. Differences in changes in exhaled nitric oxide following each dose of nitrate supplementation and compared to a standard dose of potassium nitrate at 5 hours 4. Differences in bioavailability of betalains and phenolic compounds between incremental doses of beetroot and compared to a standard dose of potassium nitrate at 5 hours	—

Measure

Time frame

1. Differences in changes in blood pressure following each dose of nitrate supplementation and compared to a standard dose of potassium nitrate at 5 hours 2. Differences in changes in endothelial function following each dose of nitrate supplementation and compared to a standard dose of potassium nitrate at 5 hours 3. Differences in changes in exhaled nitric oxide following each dose of nitrate supplementation and compared to a standard dose of potassium nitrate at 5 hours 4. Differences in bioavailability of betalains and phenolic compounds between incremental doses of beetroot and compared to a standard dose of potassium nitrate at 5 hours

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Countries

England, United Kingdom

Contacts

Public ContactTess Capper

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 19, 2026