Effect of gastric bypass surgery on body weight

Effect of gastric bypass surgery on mitochondrial function and insulin secretion and action in patients with type 2 diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN86578521

Enrollment

Registered

2015-02-17

Start date

2009-12-01

Completion date

Unknown

Last updated

2018-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin resistance Nutritional, Metabolic, Endocrine Diabetes

Interventions

Obese patients with and without type 2 diabetes will be assessed twice before and twice after Roux-en-Y gastric bypass with: 1. Intravenous glucose tolerance test 2. Oral glucose tolerance test 3. Eug

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Before 31/01/2011 1. Age 18–60 years old 2. Body mass index (BMI) >40 kg/m2 or >35kg/m2 with obesity-related comorbidities (e.g., type 2 diabetes) After 31/01/2011 1. Age 25–60 years old 2. BMI >50 kg/m2 or BMI >35kg/m2 with obesity-related comorbidities

Exclusion criteria

Exclusion criteria: 1. Endocrine diseases 2. Dysregulated hypertension 3. Hypertension requiring polypharmacy

Design outcomes

Primary

Measure	Time frame
1. Insulin action 2. Insulin secretion 3. Maximal oxygen consumption 4. Mitochondrial respiration 5. Fat oxidation during exercise	—

Secondary

Measure	Time frame
1. Body composition 2. Hepatic glucose production and mitochondrial function 3. Lipolysis 4. Incretin hormones	—

Countries

Denmark

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026