Maintenance versus pre-seasonal allergoid immunotherapy in seasonal allergic rhinitis

Maintenance versus pre-seasonal allergoid immunotherapy in seasonal allergic rhinitis: a randomized trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN86562422

Enrollment

Registered

2011-10-10

Start date

2005-10-01

Completion date

Unknown

Last updated

2016-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Seasonal allergic rhinitis Respiratory Other seasonal allergic rhinitis

Interventions

In both arms, immunotherapy will begin with a build-up phase, i.e. gradually reaching the maintenance dose (increasing volumes of 0.1 ml, 0.2 ml, 0.4 ml and 0.8 ml will be administered subcutaneously

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. History of seasonal allergic rhinitis 2. Confirmed sensitivity to grass pollen 3. More than five years of age 4. Ability to proper performance of spirometry

Exclusion criteria

Exclusion criteria: Current or past active and passive tobacco-smoking

Design outcomes

Primary

Measure	Time frame
1. Bronchial response distributions after bronchial allergen challenge (BAC) 2. Provocative concentration causing a 20% fall in forced expiratory volume in one second (PC20FEV1) 3. Maximal decrease in forced expiratory volume in one second (FEV1) determined during late asthmatic response	—

Secondary

Measure	Time frame
Nitric oxide concentration in exhaled air (FeNO) determined prior to and after bronchial allergen challenge (BAC)	—

Countries

Poland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 27, 2026