Measurements of work of breathing in newborn during respiratory support

Assessment and Measurement of Work of Breathing and Dynamic Lung Mechanics in Non-Invasive Respiratory Support: A prospective randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN86534610

Enrollment

Registered

2010-04-12

Start date

2008-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Failure Respiratory

Interventions

Each participant received nCPAP at pressure levels of 2, 4, 6 and 8 cm H2O. The sequence of the pressure levels for each subject was randomised to avoid a 'volume history effect' (an increase of lung

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Neonates requiring nCPAP 2. Weight less equal than 500g

Exclusion criteria

Exclusion criteria: 1. Parents refusing consent 2. Fraction of Inspired Oxygen (FiO2) > 0.5cc 3. Pneumothorax 4. Necrotizing Enterocolitis 5. Haemodynamically unstable 6. Imminent intubation 7. Weaning off CPAP 8. Major congenital malformation

Design outcomes

Primary

Measure	Time frame
Pressure time product All outcome variables will be measured 10 -15 minutes after each change of nCPAP level for a period of 5 minutes	—

Secondary

Measure	Time frame
1. Phase angle 2. Abdominal excursion 3. Respiratory rate 4. Expiratory time 5. FiO2 All outcome variables will be measured 10 -15 minutes after each change of nCPAP level for a period of 5 minutes	—

Countries

South Africa

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026