Overweight, non-alcoholic fatty liver disease Digestive System
Conditions
Interventions
Prebiotic nutritional supplementation: xylo-oligosaccharides 2.8 g daily in powder form.
Each participant went through a 1-month control period, followed by 4 months of dietary intervention.
Sponsors
Academy of Finland
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 1825 kg/m² 3. High waist circumference (>102 cm for males, >88 cm for females)
Exclusion criteria
Exclusion criteria: 1. Antibiotic treatment 1 month prior to the study 2. Excessive alcohol consumption (>20 g/day for females, 30 g/day for males) 3. Inflammatory bowel disease 4. Celiac disease 5. Major eating disorders 6. Hypothyroidism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in liver fat, assessed with MRI at baseline (0), pre-intervention (4 weeks), and post-intervention (16 weeks) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Responses in gut microbial composition or diversity, measured with 16S rRNA sequencing at baseline (0), pre-intervention (4 weeks), and post-intervention (16 weeks) 2. Determinants of response to the prebiotic, measured with microbiome, metabolome, GWAS at baseline (0), pre-intervention (4 weeks), and post-intervention (16 weeks) | — |
Countries
Finland
Contacts
Public ContactSatu Pekkala
Outcome results
None listed