The evaluation of the effect of platelet-rich fibrin (PRF) and xenograft used for the elimination of bone loss caused by periodontal (gum) infections on new bone formation in smokers and non-smokers

The examination of the effects of PRF and xenograft on bone regeneration in the treatment of intra-bony defects in smokers and non-smokers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN86409051

Enrollment

Registered

2021-04-26

Start date

2016-01-02

Completion date

Unknown

Last updated

2021-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intra-bony defects caused by periodontal (gum) diseases Oral Health

Interventions

Initial treatment was performed in all groups to ensure the formation of new bone in the intra-bone defects caused by periodontal infections in smokers and non-smokers. Grouping of patients was named

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Two intra-bony defects with a probing depth =5 mm, = 3 mm radiographic defect depth, = 3mm intra-bony defect depth established at the time of surgery

Exclusion criteria

Exclusion criteria: 1. The existence of any systemic diseases 2. Using antibiotics/anti-inflammatory and/or antiaggregant agents at least 6 months before treatment 3. Pregnancy

Design outcomes

Primary

Measure	Time frame
1. Probing depth (mm) was measured using a 0.5 mm diameter Williams periodontal probe at baseline, 1 month after initial treatment, the time of surgical operation, 3 months after surgical operation and 6 months after surgical operation 2. Radiological defect depth (mm) was measured on radiological images at baseline, 3 and 6 months after surgical operation	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Turkey

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026