Respiratory distress syndrome Respiratory Respiratory distress syndrome of newborn
Conditions
Interventions
The study would involve randomising the babies to low tidal volume (4-5 ml/kg) or high tidal volume (7-8 ml/kg) at birth using volume guarantee mode of ventilation. We would also collect tracheal aspi
Sponsors
North Tees and Hartlepool Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Preterm babies weighing 500-1500g or =32 weeks of gestation at birth 2. Requirement of intubation and mechanical ventilation
Exclusion criteria
Exclusion criteria: 1. Serious underlying congenital anomaly 1.1. Congenital diaphragmatic hernia 1.2. Cyanotic congenital heart disease 1.3. Airway anomalies 1.4. Abdominal wall defects 2. Multiple pregnancies ? only the first-born were enrolled and randomized; the others received the same strategy but were not be enrolled 3. Babies initiated on ventilation after 12 hours of life or transferred from other centres
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time to achieve 25% reduction in peak pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Duration of intubation 2.Incidence of pulmonary and non-pulmonary complications i.e., pneumothorax, bronchopulmonary dyplasia, intraventricular haemorrhage 3. Impact on inflammatory markers in tracheal aspirate 4. Survival to discharge | — |
Countries
United Kingdom
Outcome results
None listed