Effects of caloric restriction combined with moderate or vigorous intensity exercise on metabolic control and inflammation

Effects of caloric restriction combined with moderate or vigorous intensity short-term (three weeks) exercise training on metabolic control and inflammation in middle-aged, overweight and inactive men and postmenopausal women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN86152135

Enrollment

Registered

2013-11-19

Start date

2009-01-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, type 2 diabetes, cardiovascular disease Nutritional, Metabolic, Endocrine Obesity

Interventions

Participants were asked to complete a range of preliminary tests (e.g., body mass, maximum oxygen uptake, body composition, habitual physical activity) after which they completed a 3-week intervention

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male and postmenopausal women, aged 45 to 64 2. Overweight/obese (body mass index [BMI] >25 kg.m-2) 3. Physically inactive (no participation in regular structured exercise and they did not do >30 minutes of moderate-intensity exercise on most days of the week) 4. Weight stable (over the past 6 months)

Exclusion criteria

Exclusion criteria: 1. Smoker 2. Age outside range (64 years) 3. Positive responses to Physical Activity Readiness Questionnaire 4. Taking medication that may interfere with study 5. Doctor diagnosed condition that might interact with study measures (e.g. cardiovascular disease)

Design outcomes

Primary

Measure	Time frame
Changes in insulin sensitivity and glycaemic control. Measured at baseline and at the end of the intervention (i.e., after 21 days).	—

Secondary

Measure	Time frame
1. Other blood measures related to metabolic function and inflammation (e.g., cholesterol, non-esterified fatty acids [NEFA], triacylglycerol, alanine aminotransferase [ALT], interleukin (IL)-6, leptin, adiponectin) 2. Changes in adipose tissue gene expression related to metabolic function and inflammation were measured using real-time quantitative polymerase chain reaction (qPCR). Measured at baseline and at the end of the intervention (i.e., after 21 days).	—

Measure

Time frame

1. Other blood measures related to metabolic function and inflammation (e.g., cholesterol, non-esterified fatty acids [NEFA], triacylglycerol, alanine aminotransferase [ALT], interleukin (IL)-6, leptin, adiponectin) 2. Changes in adipose tissue gene expression related to metabolic function and inflammation were measured using real-time quantitative polymerase chain reaction (qPCR). Measured at baseline and at the end of the intervention (i.e., after 21 days).

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Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026