Adult kidney transplant recipients, living kidney donors and deceased donor organ offers. Urological and Genital Diseases
Conditions
Interventions
Donor organ ex-vivo MRI scans in a 3 Tesla MRI scanner:
MRI measures will comprise high spatial resolution relaxometry maps (T1: ultrafast-gradient-echo
T2: GRASE
T2*: multi-shot-FFE), DWI and DTI images, and MTR data. We will perform quantitative susceptibility mapping (QSM
sensitive to cellular arrangement and tissue microstructure and collect ultra-high resolution T2*-weighted and T1-weighted images.
Post-transplant MRI scans:
A 3 Tesla MRI scanner at the radiology de
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Organ-offer criteria: 1. Kidney-only offer from living or deceased donors, including both Donation after Circulatory Death (DCD) or Donation after Brain Death (DBD) donors. 2. Accepted for transplantation according to standard clinical selection criteria. 3. Donor/family/next of kin consent for research. Recipient criteria: 1. Male or Female aged 18 years or above. 2. Recipient participant who is admitted as a recipient of a kidney transplant. 3. Recipient participant is willing and able to give informed consent for participation in the study.
Exclusion criteria
Exclusion criteria: Organ-offer criteria: 1. Donor organs accepted Kidney transplants which are part of any other simultaneous transplant, such as simultaneous pancreas kidney or modified multi-visceral transplants. Recipient criteria: 1. Unwilling or unable to comply with the requirements of this protocol including the presence of any condition (physical, mental, or social) that, in the opinion of the PI, is likely to affect the recipient participants ability to comply with the study protocol. 2. Recipient participant has any contraindication to MRI (including pregnancy).
Countries
England, United Kingdom
Contacts
Public ContactMaria;Edward Kaisar;Sharples
;
Outcome results
None listed