Effect of methotrexate in post-operative wound healing in rheumatoid patients undergoing foot and ankle surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN86123456

Enrollment

400

Registered

2005-09-30

Start date

2004-05-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery: Foot and ankle Surgery Foot and ankle

Interventions

Group A: continuous methotrexate therapy for two weeks during perioperative period Group B: omit methotrexate therapy for two weeks during perioperative period Added September 2008: trial stopped du

Eligibility

Inclusion criteria

Inclusion criteria: Rheumatoid patients on methotrexate therapy undergoing foot and ankle surgery.

Exclusion criteria

Exclusion criteria: 1. Ongoing use of other immunosuppression agents. 2. Localised infection pre-operatively.

Design outcomes

Primary

Measure	Time frame
1. Rate of wound infection 2. Patient pain levels	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026