Craniopharyngioma Cancer
Conditions
Interventions
No intervention in this study.
It is a feasibility study measuring eating behaviour, appetite, functional magnetic resonance imaging (cerebral blood flow, response to food cues and resting brain netwo
Sponsors
University of Bristol
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged between 7-25 years who have a diagnosis of craniopharyngioma
Exclusion criteria
Exclusion criteria: 1. Clinically unwell requiring hospital or intensive treatment 2. Unwilling to fast 3. Patients for whom it would be unsafe to have an MRI including those with: 3.1 Certain metal implants 3.2 Tattoos with metallic ink 3.3 Metal body piercings which cannot be removed 4. Pregnancy to avoid harm to the foetus 5. Claustrophobia in the closed MRI environment or unable to tolerate the MRI scanner 6. Weight above 152kg and/or girth greater than 210cm due to size limitations of MRI scanner
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Characterisation of the severity of the tumour, treatment and pituitary dysfunction in the studied craniopharyngioma patient population. Assessed using a proforma and medical notes once patient recruited into the study. 2. Feasibility outcome (i) can sufficient patient numbers can be recruited (number recruited compared to number on clinic database). 3. Feasibility outcome (ii) patient tolerability of the number and nature of measures used in the study. Measure by an acceptability questionnaire at the end of the study session. 4. Preliminary data on the following: (i) functional MRI (using arterial spin labelling and BOLD fMRI scans), (ii) indirect calorimetry to measure resting metabolic rate, (iii) ad libitum food consumption (food choice and portion size), (iv) oral glucose tolerance test, measuring glucose, insulin, PYY, ghrelin, GLP-1 (5 time-points before and 30, 60, 90 and 120 post-glucose). (iv) Leptin will also be measured at baseline as well as a full blood count (FBC) and electrolytes (U&Es). (v) Appetite ratings are also given at the same timepoints during the OGTT. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Quality of life questionnaire (age appropriate) measured once using the MMQL. 2. Hyperphagic eating behaviour questionnaire 3. Adult or Child eating behaviour questionnaire 4. Body composition measured using multifrequency bioelectrical impedance, Tanita MC-780), to give fat-free mass and fat mass, and total body water | — |
Countries
England, United Kingdom
Outcome results
None listed