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Clinical and instrumental study on the anti-ageing effects of creams with hyaluronic acid, with and without Vitamin C

Clinical and instrumental evaluation of the anti-ageing effectiveness of a cream based on hyaluronic acid and a cream based on hyaluronic acid and Vitamin C: a prospective, multicenter, 8-week, parallel-group randomized study on 91 subjects

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN85920423
Enrollment
91
Registered
2025-07-28
Start date
2025-02-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin aging Skin and Connective Tissue Diseases

Interventions

Patients were randomized in a 1:1 ratio and instructed to apply a cream formulated with red algae and Lactobacillus, enriched with Jalubalance® technology (high-concentration hyaluronic acid delivered

Sponsors

Cantabria Labs Difacooper
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Women with mild to moderate photoaging (Glogau score 1 or 2) 2. Age between 30 and 50 years

Exclusion criteria

Exclusion criteria: 1. Pregnancy or breastfeeding 2. Allergy to components present in the products 3. Acute facial skin diseases

Design outcomes

Primary

MeasureTime frame
1. The percentage of subjects who achieved an improvement of at least one point in the hyperpigmentation score from baseline to week 8 2. Glogau score and a clinical score that assessed four parameters (wrinkles, elasticity, skin uniformity, and hyperpigmentation) with a 4-point score for each item (ranging from 0 = no issue to 3 = severe issue) from baseline to week 8

Secondary

MeasureTime frame
1. Instrumental evaluation of treatment efficacy using the Digital Skin Moisture Meter, which measures skin hydration, sebum content, and skin elasticity, from baseline to week 8 2. VISIA® objective face sculptor analysis performed in a subgroup of 10 subjects from baseline to week 8

Countries

Italy

Contacts

Public ContactStefano Alfano
stefano.alfano@difacooper.com+39 (0)3802607820

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026