Low fat versus low carbohydrate weight reduction diets: evaluation of effects on insulin resistance and cardiovascular risk

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN85769730

Enrollment

Registered

2007-02-21

Start date

2005-10-02

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity Nutritional, Metabolic, Endocrine Obesity

Interventions

The volunteers will be randomised to either a low fat or a low carbohydrate diet for eight weeks. All food for the duration of the diet will be provided. All assessments below will be carried out at b

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male and female healthy volunteers 2. Aged 18 to 65 3. Body Mass Index (BMI) greater than 27

Exclusion criteria

Exclusion criteria: 1. History of diabetes 2. coronary, hepatic or renal disease 3. Pregnancy

Design outcomes

Primary

Measure	Time frame
Assessment of insulin sensitivity by hyperinsulinaemic euglycaemic clamp	—

Secondary

Measure	Time frame
1. Body weight and composition 2. Assessment of blood pressure 3. Lipids 4. Vascular compliance 5. Adiopcykine levels 6. Pancreatic funtion	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026