Effect of postoperative nasal ventilation in patients undergoing coronary artery bypass grafting (CABG)

Effect on speed of recovery of postoperative nasal ventilation compared to conventional management in patients undergoing coronary artery bypass grafting (CABG): a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN85570732

Enrollment

200

Registered

2011-07-05

Start date

2007-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-operative care of coronary artery bypass graft (CABG) patients Circulatory System Post-operative care

Interventions

Nasal bilevel positive airway pressure (BiPAP) support added to routine post-operative care compared to routine post-operative care

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Any patient accepted for elective CABG surgery

Exclusion criteria

Exclusion criteria: 1. Pre-existing significant renal (creatinine>200 umol/L), hepatic or haematological disease 2. Poor left ventricular function 3. Chronic infection 4. Emergency surgery

Design outcomes

Primary

Measure	Time frame
Hospital length of stay from day of operation to day of fitness-to-discharge-until day when judged fit-for-discharge on the basis of clinical criteria	—

Secondary

Measure	Time frame
1. Lung function and blood gases-Lung function: 1.1. Pre-op lung function is done within 4 weeks of the operation (bed-side spirometry, and then formal departmental spirometry). In patients with a significant obstructive defect {defined as an FEV1 < 70% or [forced expiratory volume in one second (FEV1)/forced vital capacity (FVC )] of < 70%}, spirometry is then done before and after bronchodilator administration as well as body plethysmography for lung volumes and gas transfer. 1.2. Respiratory muscle strength, measured as mouth pressures [maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP)] have been measured on majority of patients. 1.3. Post-operative lung function is measured on day 1, 2 and 3 by bed-side spirometry with documentation of oxygen (O2) saturation and fraction of inspired oxygen (FiO2) given to patient. 1.4. Arterial Blood gases: Are measured preoperatively as a baseline, just before the operation. ABG are measured after the operation at the time of ex-tubation, 1hour later, 12 hours later and 24 hours from the time of ex-tubation. The Fio2 is documented for each measurement 2. Intensive treatment unit (ITU) length of stay 3. Occurrence of complications	—

Measure

Time frame

1. Lung function and blood gases-Lung function: 1.1. Pre-op lung function is done within 4 weeks of the operation (bed-side spirometry, and then formal departmental spirometry). In patients with a significant obstructive defect {defined as an FEV1 < 70% or [forced expiratory volume in one second (FEV1)/forced vital capacity (FVC )] of < 70%}, spirometry is then done before and after bronchodilator administration as well as body plethysmography for lung volumes and gas transfer. 1.2. Respiratory muscle strength, measured as mouth pressures [maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP)] have been measured on majority of patients. 1.3. Post-operative lung function is measured on day 1, 2 and 3 by bed-side spirometry with documentation of oxygen (O2) saturation and fraction of inspired oxygen (FiO2) given to patient. 1.4. Arterial Blood gases: Are measured preoperatively as a baseline, just before the operation. ABG are measured after the operation at the time of ex-tubation, 1hour later, 12 hours later and 24 hours from the time of ex-tubation. The Fio2 is documented for each measurement 2. Intensive treatment unit (ITU) length of stay 3. Occurrence of complications

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026