Patients >65 years of age undergoing laparoscopic major non-cardiac surgery under general anesthesia Surgery Laparoscopic major non-cardiac surgery under general anesthesia
Conditions
Interventions
Participants are randomly assigned following simple randomization procedures (computerized random numbers) to 1 of 3 treatment groups:
1. Group D1 receive dexmedetomidin in a 1 µg/kg bolus followed b
however, anesthesiologists and nurses are not because they needed to adjust the timing and dose of dexmedetomidine. The researchers who assess the outcomes are, however, blinded.
Participants are ass
Sponsors
Wonkwang University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients > 65 years of age 2. Classified as class I or III according to the American Society of Anesthesiologists (ASA) 3. Scheduled for laparoscopic major non-cardiac surgery under general anesthesia
Exclusion criteria
Exclusion criteria: 1. Patients with a history of kidney or liver disease 2. History of allergy to the drug being studied 3. Cognitive impairment 4. Use of antipsychotic alpha-2 agonists or antagonist medications 5. Use of anti-inflammatory drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium is mesaured using the confusion assessment method (CAM) for 5 days after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Duration of delirium is measured using the confusion assessment method (CAM) up to five days after surgery 2. Cortisol levels are measured using saliva samples at one and 24 hours after surgery 3. C-reactive protein (CRP), and cytokine (tumor necrosis factor [TNF]-alpha, interleukin [IL]-1ß, IL-2, IL-6, IL-8, and IL-10) levels measured using blood samples at one and 24 hours after surgery | — |
Countries
Korea, South
Outcome results
None listed