Experimental human pneumococcal carriage

Can Experimental Pneumococcal Carriage in healthy volunteers be established – what dose and strain is best?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN85403723

Enrollment

200

Registered

2016-08-25

Start date

2011-10-21

Completion date

Unknown

Last updated

2023-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Specialty: Infectious diseases and microbiology, Primary sub-specialty: Antimicrobial therapy Infections and Infestations Pneumococcal infection

Interventions

Dose ranging study: 120 healthy adult volunteers are allocated into 10 groups of 10, and are inoculated with 0.1ml pneumococci (well-characterised penicillin sensitive) to each nostril

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults aged 18-60 years old 2. Fluent English spoken

Exclusion criteria

Exclusion criteria: 1. Close contact with young children, elderly or immunocompromised individuals (either at work or home) 2. Asthma or pre-existing lung disease 3. Cigarette smoking of greater than 20 pack years 4. Chronic illness 5. Pregnancy 6. Penicillin allergy

Design outcomes

Primary

Measure	Time frame
Presence of pneumococci is measured using classical culture methods in nasal wash at 48 hours and/or 7 days following inoculation.	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 6, 2026