Paraquat poisoning Injury, Occupational Diseases, Poisoning Paraquat poisoning
Conditions
Interventions
Two days of cyclophosphamide 750 mg (if weight is less than 50 kg) or one gram (if weight is more than 50 kg), and three days of methylprednisolone one gram both by intravenous infusion over one hour.
Sponsors
South Asian Clinical Toxicology Research Collaboration (SACTRC) (Sri Lanka)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with a history of acute paraquat poisoning 2. Presenting within 24 hours of paraquat ingestion with evidence of paraquat intoxication by urinary dithionite test
Exclusion criteria
Exclusion criteria: 1. Under 14 years 2. Pregnant 3. Systolic blood pressure of less than 70 mmHg, unresponsive to one litre fluid challenge, Glasgow Coma Score (GCS) less than 8/15, or cyanosis 4. Already received cyclophosphamide or methylprednisolone for this episode of poisoning 5. Allergic to cyclophosphamide, methylprednisolone, dexamethasone or mesna 6. Unable to give consent, or not accompanied by a relative, where the hospital consultant prefers that consent be obtained from a relative rather than the consultant looking after the patient 7. Present more than 24 hours after paraquat ingestion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality in hospital | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. All-cause mortality at three months post-ingestion 2. Lung function in survivors at three months | — |
Countries
Sri Lanka
Outcome results
None listed