Mechanical ventilation in critically ill adult patients Respiratory Mechanical ventilation in critically ill patients
Conditions
Interventions
The enrolled patients were randomized into two groups: the methadone group (MG), for whom intravenous fentanyl was replaced with enteral methadone
and the control group (CG), who underwent a gradual reduction of intravenous fentanyl.
1. The MG received the following treatment:
1.1. One capsule of methadone (10 mg) was administered enterally eve
Sponsors
Sao Jose Municipal Hospital (Brazil)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The subjects studied were severely ill patients who required MV and the continuous use of fentanyl and who met the following inclusion criteria: 1.1. MV for at least five days 1.2. The use of fentanyl analgesia in varying doses for at least five day or 1.3. A dose of fentanyl more than or equal to 5 µg/kg/h for at least 12 days. 2. Subjects were also required to meet the following ventilation weaning criteria: 2.1. Reversal of the process that caused the respiratory failure 2.2. Adequate oxygenation (PaO2/FiO2) > 200 2.3. Positive end-expiratory pressure (PEEP) less than or equal to 5; FiO2 less than or equal to 0.4 and pH more than or equal to 7.25 2.4. Hemodynamic stability (with minimal or no vasoactive drugs) and neurological stability (ability to initiate respiratory effort)
Exclusion criteria
Exclusion criteria: 1. Patients younger than 18 years 2. Patients with terminal diseases 2. Patients with cervical spinal cord injuries or neuromuscular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of ventilation weaning (weaning success was defined as 48 hrs without reinstitution of mechanical ventilation) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Duration of mechanical ventilation 2. Length of ICU stay 3. Length of hospital stay | — |
Countries
Brazil
Outcome results
None listed