Determining the acceptability and efficacy of new approaches for dengue vector control in Cambodia

Determining the acceptability and efficacy of guppies, pyriproxyfen, and community engagement on dengue vectors in Cambodia: A cluster randomized trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN85307778

Enrollment

21722

Registered

2015-10-26

Start date

2015-02-27

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dengue fever Infections and Infestations Dengue fever

Interventions

Public Randomization was selected as the method by which to randomize villages to evaluation arms. Village chiefs from all 30 clusters and HC chiefs from all seven HCs were invited to a central point

Arm 3. Control (no intervention) Guppies The use of guppy fish (Poecilia reticulata) is a low cost, sustainable and effective approach to reduce dengue vector populati

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All households

Exclusion criteria

Exclusion criteria: N/A

Design outcomes

Primary

Measure	Time frame
Density of resting adult female Aedes agypti in the household as measured by entomology surveys at baseline, 4, 8 and 12 months.	—

Secondary

Measure	Time frame
1. Proportion of houses surveyed positive for Aedes aegypti larvae and/or pupae in any water container as measured by entomology surveys at baseline, 4, 8 and 12 months 2. Proportion of surveyed containers containing Aedes aegypti larvae and/or pupae as measured by entomology surveys at baseline, 4, 8 and 12 months 3. Number of containers positive for Aedes aegypti larvae and/or pupae per 100 houses surveyed as measured by entomology surveys at baseline, 4, 8 and 12 months 4. Number of pupae per household as measured by entomology surveys at baseline, 4, 8 and 12 months 5. Number of pupae per person as measured by entomology surveys at baseline, 4, 8 and 12 months 6. Percentage of wild caught mosquitos positive for dengue virus as measured by entomology surveys at baseline, 4, 8 and 12 months 7. Proportion of water containers with = 1 guppy fish as measured by entomology surveys at baseline, 4, 8 and 12 months and monthly monitoring by community volunteers 8. Proportion of water containers with at least 1 Sumilarv© 2MR as measured by entomology surveys at baseline, 4, 8 and 12 months and monthly monitoring by community volunteers 9. Percentage of households that have knowledge of mosquitos transmitting dengue and understand that they bite during the day as measured by a knowledge, attitudes, and practice survey at baseline and 12 months	—

Measure

Time frame

1. Proportion of houses surveyed positive for Aedes aegypti larvae and/or pupae in any water container as measured by entomology surveys at baseline, 4, 8 and 12 months 2. Proportion of surveyed containers containing Aedes aegypti larvae and/or pupae as measured by entomology surveys at baseline, 4, 8 and 12 months 3. Number of containers positive for Aedes aegypti larvae and/or pupae per 100 houses surveyed as measured by entomology surveys at baseline, 4, 8 and 12 months 4. Number of pupae per household as measured by entomology surveys at baseline, 4, 8 and 12 months 5. Number of pupae per person as measured by entomology surveys at baseline, 4, 8 and 12 months 6. Percentage of wild caught mosquitos positive for dengue virus as measured by entomology surveys at baseline, 4, 8 and 12 months 7. Proportion of water containers with = 1 guppy fish as measured by entomology surveys at baseline, 4, 8 and 12 months and monthly monitoring by community volunteers 8. Proportion of water containers with at least 1 Sumilarv© 2MR as measured by entomology surveys at baseline, 4, 8 and 12 months and monthly monitoring by community volunteers 9. Percentage of households that have knowledge of mosquitos transmitting dengue and understand that they bite during the day as measured by a knowledge, attitudes, and practice survey at baseline and 12 months

—

Countries

Cambodia

Contacts

Public ContactJohn Hustedt

john.hustedt@lshtm.ac.uk+855 898 63204

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 9, 2026