Characterization of critically ill patients with severe bacterial infections using cardiovascular MRI

Characterization of critically ill patients with septic shock and sepsis-associated cardiomyopathy using cardiovascular MRI – a pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN85297773

Enrollment

Registered

2020-07-21

Start date

2016-04-01

Completion date

Unknown

Last updated

2022-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis-associated cardiomyopathy in septic shock Circulatory System

Interventions

Participants receive one cardiac MRI during septic shock, specifically between 24 and 72 hours after peak dose of norepinephrine. MRI protocol includes cardiac function assessment using cine imaging a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Septic shock requiring catecholamine treatment despite sufficient fluid resuscitation

Exclusion criteria

Exclusion criteria: 1. Any absolute contraindication for MRI 2. Chronic renal failure with GFR < 30 ml/min/m² at time of inclusion (with the exception of patients on dialysis) 3. Myocardial infarction < 6 months before inclusion 4. Previously known LVEF < 40% at inclusion

Design outcomes

Primary

Measure	Time frame
Mean myocardial T2 time measured using MRI at 24-72 hours after peak of norepinephrine	—

Secondary

Measure	Time frame
1. Left ventricular ejection fraction measured using MRI at 24-72 hours after peak of norepinephrine 2. Myocardial T1 time measured using MRI at 24-72 hours after peak of norepinephrine 3. Right ventricular ejection fraction measured using MRI at 24-72 hours after peak of norepinephrine 4. Left ventricular ejection fraction measured using echocardiography at 48 and 96hours after the MRI scan 5. Late gadolinium enhancement measured using MRI at 24-72 hours after peak of norepinephrine	—

Measure

Time frame

1. Left ventricular ejection fraction measured using MRI at 24-72 hours after peak of norepinephrine 2. Myocardial T1 time measured using MRI at 24-72 hours after peak of norepinephrine 3. Right ventricular ejection fraction measured using MRI at 24-72 hours after peak of norepinephrine 4. Left ventricular ejection fraction measured using echocardiography at 48 and 96hours after the MRI scan 5. Late gadolinium enhancement measured using MRI at 24-72 hours after peak of norepinephrine

—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 12, 2026