Caries development in Sjögren’s syndrome patients Oral Health
Conditions
Interventions
Sjögren’s syndrome patients were randomly assigned to receive either professionally applied fluoride varnish or placebo gel quarterly. Development and arrest of caries at the coronal and root surfaces
Sponsors
Research Grants Council of Hong Kong
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of Sjögren’s syndrome established using the American-European Consensus Group (AECG) criteria at least 6 months before the commencement of this study 2. Age 18 or above 3. Had 8 or more natural teeth present
Exclusion criteria
Exclusion criteria: 1. Severe periodontal disease (e.g., periodontal pockets were deeper than 6 mm) at two or more sextants 2. Received therapeutic irradiation to the head and neck region 3. Had concurrent systemic illness (except connective tissue disorder associated with secondary Sjögren’s syndrome) 4. Taking medication that altered salivary flow 5. Had participated in a clinical trial within 6 months before commencement of this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Caries at the coronal and root surface evaluated using the International Caries Detection and Assessment System (ICDAS) at 12 months and 24 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Counts of lactobacilli and Candida (expressed as colony forming units per milliliter (CFU/ml) in salivary samples and colony forming units per gram in dental plaque samples) evaluated at 12 months and 24 months | — |
Countries
Hong Kong
Outcome results
None listed