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A randomised, placebo controlled trial of prednisone in early Henoch Schonlein Purpura

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN85109383
Enrollment
40
Registered
2004-03-09
Start date
1996-09-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Henoch Schonlein Purpura Haematological Disorders Coagulation defects, purpura and other haemorrhagic conditions

Interventions

Intervention: Prednisone 2 mg/kg for 7 days, 75% on days 8 and 9, 50% on days 10 and 11 and 25% on days 12, 13, 14, then stopped. Control: Comparison group was an identical appearing placebo.

Sponsors

Children's Hospital of Eastern Ontario Research Institute (CHEORI) (Canada)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Eligible participants were children between the ages of 2 and 15, presenting to the emergency room within 7 days of onset of Henoch Schonlein Purpura. Children were excluded if: 1. Another explanation for purpura was present 2. They had a known underlying systemic vasculitis 3. They had been treated with any form of corticosteroids in the preceding month 4. They had a known chronic illness affecting the renal, gastrointestinal or immune systems 5. They had an active infection 6. They were experiencing a life-threatening complication of Henoch Schonlein Purpura

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

MeasureTime frame
Not provided at time of registration

Secondary

MeasureTime frame
Not provided at time of registration

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 6, 2026