Cardiac surgery Circulatory System
Conditions
Interventions
Participants undergoing CABG are divided into three groups which receive a dose of supplement/placebo 12 hours before surgery:
1. Administration of 2 gr l-carnitine
2.
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective on-pump CABG for the first time 2. Adult aged 18 - 80 years 3. No history of NSAIDs and or corticosteroids use for four weeks before the operation 4. No history of inflammatory disorder for six months before the operation
Exclusion criteria
Exclusion criteria: 1. Renal failure or creatinine level >1.5 mg/d 2. Hepatic failure 3. Inability to swallow oral medications 4. Contraindication to L-carnitine therapy 5. Emergent CABG 6. Use of L-carnitine within 4 weeks before the start of the study 7. Major surgery less than 28 days before the start of treatment 8. Recent history of any cancer 9. Prior radiotherapy or chemotherapy less than 4 weeks prior 10. Moderate to severe left ventricular dysfunction (EF<40) 11. Re-operation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured by CBC differential blood test pre-operatively and daily for three days post-surgery: 1. Neutrophil-Lymphocyte ratio 2. Platelet-Lymphocytes ratio | — |
Secondary
| Measure | Time frame |
|---|---|
| Pre-operatively and daily for three days post-surgery: 1. Echocardiographic indexes measured using ECG 2. The changes of mean platelet volume measured by CBC differential blood test 3. The changes of red cell distribution width measured by CBC differential blood test | — |
Countries
Iran
Outcome results
None listed