Magnesium deficiency as a reversible driver of vascular complications in patients with type 1 diabetes Nutritional, Metabolic, Endocrine
Conditions
Interventions
Magnesium supplement - 360mg magnesium bisglycinate. This will correspond to 2 ‘active magnesium-rich’ tablets/capsules per day (will be taken orally, in a single sitting).
Placebo - This will corres
Sponsors
University of Leeds
Eligibility
Sex/Gender
All
Age
18 Years to 110 Years
Inclusion criteria
Inclusion criteria: 1. Type 1 diabetes for a minimum of 3 years (supported by clinical history and antibody testing (if available)). 2. Not on any other repeated prescription treatment other than insulin with the exception of stable adjunctive therapy for at least 3 months (including metformin, GLP-1 receptor agonists and gliflozins), long term contraceptive, long term hormonal therapy (including but not limited to thyroxine and hydrocortisone) or vitamin D and B12 supplementation. Treatment with any lipid lowering agents (such as statins) and any antihypertensive agents will also be allowed. 3. Aged 18 and over. 4. Has capacity to consent
Exclusion criteria
Exclusion criteria: 1. Significant microvascular or macrovascular complications (any retinopathy other than grade I, significant and persistent microalbuminuria, estimated glomerular filtration rate <60 ml/kg/min or clinical neuropathy) 2. Any treatment other than insulin, metformin, GLP-1RA, gliflozin, lipid or blood pressure lowering agents, long term contraceptive, long term hormonal therapy (including but not limited to thyroxine and hydrocortisone) or vitamin D and B12 supplementation. 3. Pregnancy (or planning pregnancy) 4. Any diabetes other than T1D 5. Individuals with a history of clinically symptomatic coronary artery, cerebrovascular or peripheral vascular disease will also be excluded. 6. History of cancer (active or previous) 7. History of deep venous thrombosis and/or pulmonary embolism within 6 months of study enrollment. 8. Evidence of thrombophilia.
Countries
England, United Kingdom
Contacts
Public ContactJulie Bailey
Outcome results
None listed