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The use of a flexible (GnRH) antagonist versus minidose long GnRH agonist for ovarian stimulation in poor-responder patients undergoing the (IVF) program

Effectiveness of a flexible GnRH antagonist versus minidose long GnRH agonist in poor-responder patients undergoing IVF: a prospective randomized trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN84867406
Enrollment
124
Registered
2011-07-29
Start date
2009-01-10
Completion date
Unknown
Last updated
2017-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Poor ovarian response to ovarian stimulation in IVF Pregnancy and Childbirth Female infertility

Interventions

1. Random allocation was performed by an IVF physician at the start of the study using consecutive number method in 1:1 ratio 2. In this prospective randomized trial, participants were randomly assig

Sponsors

Al-Amal Maternity Hospital (Jordan)
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Participants were poor responders to ovarian stimulation undergoing IVF program and defined as 1. Women who developed less than four oocytes in previous IVF cycles 2. Women with high basal Follicle-stimulating hormone (FSH) level (>10IU/L)

Exclusion criteria

Exclusion criteria: 1. Patients with intrauterine pathology (endometrial polyp, intrauterine septum) 2. Patients with polycystic ovaries 3. Patients with ovarian cyst, detected on second day of cycle (baseline evaluation)

Design outcomes

Primary

MeasureTime frame
The clinical pregnancy rate per embryo transfer

Secondary

MeasureTime frame
1. Required gonadotrophin dose 2. Days of stimulation 3. Estradiol on day of human chorionic gonadotropin (HCG) 4. Progesterone on day of HCG 5. Number of oocytes retreived 6. Number of fertilized oocytes 7. Number of embryos obtained 8. Number of embryos transferred

Countries

Jordan

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026