Vestibular neuronitis Ear, Nose and Throat Disorders of vestibular function
Conditions
Interventions
All patients who are diagnosed as VN and have signed informative consent forms will be randomised in one of two groups (A or B):
1. Patients in group A will receive dexamethasone 12 mg
Sponsors
University Hospital Centre Zagreb (Croatia)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients older than 18 years of age (either sex) who will be diagnosed as vestibular neuronitis in the emergency neurology department based on the following criteria: 1. Persistent rotatory vertigo which started up to 48 hours 2. Horisontal-torsional nystagmus, unidirectional, more pronounced on removing fixation 3. Positive head thrust test on the side of vestibular lesion 4. Absence of skew deviation (assessed by Maddox rod test) 5. Normal brain multi-slice computed tomography (MSCT) 6. Normal electrocardiogram (ECG) 7. Normal laboratory findings (complete blood count [CBC], prothrombin time [PT], activated partial thromboplastin time [APTT], blood glucose level, urea, creatinine, aspartate aminotransferase [AST], alanine aminotransferase [ALT], gamma-glutamyl transferase [GGT], creatine kinase [CK], lactate dehydrogenase [LD])
Exclusion criteria
Exclusion criteria: 1. Loss of hearing 2. Tinnitus 3. Presence of any neurological deficit 4. Medical history containing data of: 4.1. Unregulated arterial hypertension 4.2. Atrial fibrillation 4.3. Diabetes mellitus 5. Patients taking: 5.1. Corticosteroids 5.2. Benzodiazepines 5.3. Patients who have contraindications for taking corticosteroids and benzodiazepines
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Necessity to hospitalise patients who present with VN in the emergency department. All outcomes will be measured at the admittance to the emergency department and 120 mins after the treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Improvement of nystagmus (grading by Alexander) 2. Improvement of postural instability (grading by Fukuda test) 3. Lessening of nausea (according of visual-analog scale) 4. Lessening of vomiting 5. Recovery of subjective symptoms (according to European Evaluation of Vertigo scale) All outcomes will be measured at the admittance to the emergency department and 120 mins after the treatment. | — |
Countries
Croatia
Outcome results
None listed