Aphasia following stroke Nervous System Diseases
Conditions
Interventions
24 patients with aphasia were randomly divided into 3 groups using Excel, and received hand-action observation and repetition, dynamic-object observation and repetition, and conventional speech therap
Sponsors
the First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Stroke patients with aphasia: 1. First occurrence of cerebral infarction or hemorrhage 2. Aged 35–70 years 3. Disease course lasting for 3–24 months 4. Right-handed according to the Edinburgh Handedness Inventory 5. Educated beyond primary school (more than 5 years of education) 6. Aphasia determined by Western Aphasia Battery (WAB) (aphasia quotient 70) 8. Retaining part of the auditory ability and tolerance of more than 30 minutes to complete the daily training task Healthy participants: 9. Right-handedness according to the Edinburgh Handedness Inventory 10. Aged 18–30 years 11. Over 12 years of education 12. Willing to participate in the experiment and able to tolerate the experiment
Exclusion criteria
Exclusion criteria: Stroke patients with aphasia: 1. Frenchay dysarthria assessment shows moderate to severe dysarthria 2. Serious speech apraxia or oral and maxillofacial apraxia 3. Anxiety determined by Hamilton Anxiety Scale or depression determined by Hamilton Depression Scale 4. Obvious dyssomnia or emotional disturbances 5. Other diseases likely to aggravate patient’s functional status such as cancer, severe heart or lung disease 6. Refused training or no desire for training 7. Severe pain, i.e. pain >8 out of 10 on a visual analog scale (VAS) Healthy participants: 7. Poor physical condition for any reason 8. Refused training or no desire for training
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Language function assessed using the Western aphasia battery (WAB), including four sub-tests of oral language (i.e., spontaneous speech, auditory verbal comprehension, repetition, and naming) and aphasia quotient, before and after 2 weeks of training | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Naming of pictured objects. 180 pictures of objects selected from standardized picture naming norms in Mandarin were divided into three groups and used as the naming materials at 0 week (before treatment) and after 1 and 2 weeks of treatment. 2. Naming of pictured actions. 120 pictures of actions were selected from the Russian language and neuropsychological research online database (http://neuroling.ru/en/analog.htm), divided into three groups and used as the naming materials at 0 week (before treatment) and after 1 and 2 weeks of treatment. 3. Functional magnetic resonance imaging (fMRI) measurements. The fMRI experiment was carried out to investigate the influence of hand-action observation on language function and corresponding neurophysiology mechanism underlying MNS. This was done immediately after intervention. | — |
Countries
China
Contacts
Public ContactWen-Li Chen
Outcome results
None listed