Effects of Voluven® infusion on plasma volume, serum biochemistry and sodium and water controlling hormones Not Applicable
Conditions
Interventions
Double blind, randomised crossover study
Sponsors
Record Provided by the NHSTCT Register - 2006 Update - Department of Health
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Male subjects aged between 18 and 40 years responding to local advertisement will be screened by questionnaire and medical examination before being chosen.
Exclusion criteria
Exclusion criteria: Subjects weighing less than 65kg or more than 80kg, those with medical conditions or allergies, those on regular medications, and participants in a study less than three months before will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in effects produced by the two infusions on haemotocrit, serum albumin, chloride, osmolality, AVP, renin, ANP and aldosterone. Differences betwen the infusions will be tested for statistical significance using the Wilcoxon signed ranks test and repeated measures ANOVA. Differences will be considered significant if P<0.05. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed