Cancer: Pancreatic Cancer Pancreatic
Conditions
Interventions
Randomised test intervention vs standardised intervention, non-blinded (Phase III)
Sponsors
Record Provided by the NHSTCT Register - 2006 Update - Department of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age over 18 - pancreatic adenocarcinoma is unusual below this age and children are more sensitive to additional ionising radiation than adults 2. Stage III ovarian cancer or colorectal cancer 3. Routine attendance for contrast enhanced abdominal CT - no patients not otherwise having CT and contrast will be approached.
Exclusion criteria
Exclusion criteria: 1. Severe local disease affecting pancreatic aorta/branches. This may introduce delays to the arrival of contrast due to compromise of arteries (SMA/Coeliac axis) 2. Major atherosclerotic disease of SMA/Coeliac axis - again, to avoid significant delay in contrast path distal to pancreatic aorta 3. Significant pancreatic resection - absence of normal pancreatic tissue will preclude our numerical assessment of enhancement 4. Pre-existing pancreatic disease - cancer or pancreatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Absolute value of the Hounsfield attenuation in normal pancreatic tissue at pancreatic parenchymal phase. 2. Clinical radiologist's impression on the utility/benefit of mucosal enhancement of adjacent duodenum in aiding local staging. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed