Polycystic ovary syndrome Nutritional, Metabolic, Endocrine Ovarian dysfunction
Conditions
Interventions
Both PCOS and non-PCOS women underwent the same study protocol. From baseline, participants in the two groups undertook a 12 week programme of supervised intensified endurance exercise (1 hr/day
3 x per week). Two different exercise sessions alternated, performing 1 hour of moderate intensity treadmill walking to elicit work rates of 70% of maximal oxygen consumption (VO2max) or 75 - 85% of m
Sponsors
Southern Health (Australia)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Overweight women (body mass index [BMI] greater than 27 kg/m^2) 2. Aged 18 - 40 years with PCOS and without 3. Diagnosed from a history of perimenarchal onset of irregular cycles (less than 21 days or greater than 35 days) 4. Clinical manifestations of hyperandrogenism (hirsutism, acne) or biochemical hyperandrogenism with elevation of at least one circulating ovarian androgen (1990 National Institute of Health [NIH] criteria)
Exclusion criteria
Exclusion criteria: 1. BMI less than 27 kg/m^2 2. Other concurrent medical conditions 3. Ongoing use of the oral contraceptive pill (OCP) 4. Pregnancy or desire for pregnancy 5. Secondary causes of amenorrhoea and hyperandrogenism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects on insulin resistance, measured at baseline and after 12 weeks of exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical symptom improvement 2. Insulin signalling 3. Mitochondrial function Measured at baseline and after 12 weeks of exercise. | — |
Countries
Australia
Outcome results
None listed