Topic: Renal and Urogenital
Conditions
Interventions
Antihypertensive therapy using standard agents to target BP 130/80 mmHg. Assessments are performed after antihypertensive washout, reintroduction and 12 months follow up.
Sponsors
Derby Hospital NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged greater than 70 years 2. CKD 3, 4 or hypertensive (greater than 130/80) with no renal disease
Exclusion criteria
Exclusion criteria: 1. Use of more than 3 drugs for blood pressure control 2. Likely to develop CKD 5 within one year 3. Poor mobility precluding completion of assessment 4. Diabetes 5. Abbreviated mental test (AMT) score 160/90mmHg 13. Malignant hypertension 14. Severe peripheral vascular disease or significant valvular heart disease 15. Heart failure (NYHA III/IV) or other cause to prevent diuretic withdrawal 16. Atrial fibrillation or other significant arrhythmia (precludes pulse wave velocity (PWV) measurement) 17. Currently taking antihypertensive medication for which MRHA approval (CTA) has not been granted 18. Active Obstructive uropathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Baroreflex sensitivity (a composite marker of autonomic function) in response to antihypertensive therapy, assessed at each assessment | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessed at each assessment: 1. Cardiovascular predictors of Falls propensity 2. Cardiovascular consequences of antihypertensive therapy | — |
Countries
United Kingdom
Outcome results
None listed